Research & Development
Current research collaborations and a selection of our team's impact in the field of precision medicine.
Research Collaborations
2023-2025 EU Horizon 2020 Research and Innovation Programme
SME Partner, Funding under Grant agreement ID: 964874
Using real-world big data from eHealth, biobanks and national registries, integrated with clinical trial data to improve outcome of severe mental disorders.
With a large number of patients lacking efficient treatment options, mental disorders represent one of the biggest burdens for the European healthcare system. Current treatments are based on a trial-and-error approach; as multi-morbidities are frequent, this often leads to polypharmacy and poor outcomes. The EU-funded REALMENT project aims to optimise the treatment of mental disorders through novel precision medicine strategies based on current pharmaceutical options. The project's efforts will bring world-leading research institutes and the pharmaceutical industry at the forefront of mental disorder research.
2023-2025 EU Horizon 2020 Research and Innovation Programme
SME Partner - Funding under Grant agreement ID: 84776
Predicting comorbid cardiovascular disease in individuals with mental disorder by decoding disease mechanisms.
Comorbid cardiovascular disease in cases of severe mental disorders is a major public health concern. Recent findings show that genetic variations that affect the brain and increase the risk of mental disorders also impact lifestyle and behaviour that increase risk of cardiovascular disease. The EU-funded project CoMorMent will investigate mechanisms underlying the higher incidence of cardiovascular disease in people with mental disorders. The study will take advantage of 1.8 million genotyped biobank samples from national registries with information about disease trajectories and comorbidity. It will uncover the underlying molecular mechanisms by identifying structural brain changes and body fat composition in combination with gene expression and functional studies. Ultimately, this project will help to create the basis for a new approach in clinical studies by providing precision medicine tools to deal with a major public health issue.
2023-2027 The Research Council of Norway: Collaborative & Knowledge-building Project - Funding under Project Nr: 344121
Multimodal digital avatar tools for early diagnosis of dementia in municipalities
The main aim is to enable the municipality health service to meet the increasing demand for early diagnosis of dementia and position the Norwegian healthcare sector for emerging treatment alternatives. This will provide a person with dementia a timely and precise diagnosis, enabling earlier interventions and personalized healthcare.
Scientific Publications
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Alzheimer's Disease
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Prostate Cancer
McEvoy LK, Fennema-Notestine C, Roddey JC, Hagler DJ Jr, Holland D, Karow DS, Pung CJ, Brewer JB, Dale AM; Alzheimer's Disease Neuroimaging Initiative.
Radiology
DOI:
10.1148/radiol.2511080924
Walhovd KB, Fjell AM, Brewer J, McEvoy LK, Fennema-Notestine C, Hagler DJ Jr, Jennings RG, Karow D, Dale AM; Alzheimer's Disease Neuroimaging Initiative.
AJNR Am J Neuroradiol
DOI:
10.3174/ajnr.A1809
McEvoy LK, Holland D, Hagler DJ Jr, Fennema-Notestine C, Brewer JB, Dale AM; Alzheimer's Disease Neuroimaging Initiative.
Radiology
DOI:
10.1148/radiol.11101975
Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen CH, Brewer JB, Karow DS, Kauppi K, Witoelar A, Karch CM, Bonham LW, Yokoyama JS, Rosen HJ, Miller BL, Dillon WP, Wilson DM, Hess CP, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Hardy J, Goate AM, Hyman BT, Schellenberg GD, McEvoy LK, Andreassen OA, Dale AM.
PLoS Med
DOI:
10.1371/journal.pmed.1002258
Kauppi K, Fan CC, McEvoy LK, Holland D, Tan CH, Chen CH, Andreassen OA, Desikan RS, Dale AM; Alzheimer's Disease Neuroimaging Initiative.
Front Neurosci
DOI:
10.3389/fnins.2018.00260
Motazedi E, Cheng W, Thomassen JQ, Frei O, Rongve A, Athanasiu L, Bahrami S, Shadrin A, Ulstein I, Stordal E, Brækhus A, Saltvedt I, Sando SB, O'Connell KS, Hindley G, van der Meer D, Bergh S, Nordestgaard BG, Tybjærg-Hansen A, Bråthen G, Pihlstrøm L, Djurovic S, Frikke-Schmidt R, Fladby T, Aarsland D, Selbæk G, Seibert TM, Dale AM, Fan CC, Andreassen OA.
J Alzheimers Dis
DOI:
10.3233/JAD-220174
Reas ET, Shadrin A, Frei O, Motazedi E, McEvoy L, Bahrami S, van der Meer D, Makowski C, Loughnan R, Wang X, Broce I, Banks SJ, Fominykh V, Cheng W, Holland D, Smeland OB, Seibert T, Selbaek G, Brewer JB, Fan CC, Andreassen OA, Dale AM; Alzheimer's Disease Neuroimaging Initiative.
Alzheimers Dement
DOI:
10.1002/alz.13112
Seibert TM, Fan CC, Wang Y, Zuber V, Karunamuni R, Parsons JK, Eeles RA, Easton DF, Kote-Jarai Z, Al Olama AA, Garcia SB, Muir K, Grönberg H, Wiklund F, Aly M, Schleutker J, Sipeky C, Tammela TL, Nordestgaard BG, Nielsen SF, Weischer M, Bisbjerg R, Røder MA, Iversen P, Key TJ, Travis RC, Neal DE, Donovan JL, Hamdy FC, Pharoah P, Pashayan N, Khaw KT, Maier C, Vogel W, Luedeke M, Herkommer K, Kibel AS, Cybulski C, Wokolorczyk D, Kluzniak W, Cannon-Albright L, Brenner H, Cuk K, Saum KU, Park JY, Sellers TA, Slavov C, Kaneva R, Mitev V, Batra J, Clements JA, Spurdle A, Teixeira MR, Paulo P, Maia S, Pandha H, Michael A, Kierzek A, Karow DS, Mills IG, Andreassen OA, Dale AM; PRACTICAL Consortium*.
BMJ
DOI:
10.1136/bmj.j5757
Huynh-Le MP, Fan CC, Karunamuni R, Thompson WK, Martinez ME, Eeles RA, Kote-Jarai Z, Muir K, Schleutker J, Pashayan N, Batra J, Grönberg H, Neal DE, Donovan JL, Hamdy FC, Martin RM, Nielsen SF, Nordestgaard BG, Wiklund F, Tangen CM, Giles GG, Wolk A, Albanes D, Travis RC, Blot WJ, Zheng W, Sanderson M, Stanford JL, Mucci LA, West CML, Kibel AS, Cussenot O, Berndt SI, Koutros S, Sørensen KD, Cybulski C, Grindedal EM, Menegaux F, Khaw KT, Park JY, Ingles SA, Maier C, Hamilton RJ, Thibodeau SN, Rosenstein BS, Lu YJ, Watya S, Vega A, Kogevinas M, Penney KL, Huff C, Teixeira MR, Multigner L, Leach RJ, Cannon-Albright L, Brenner H, John EM, Kaneva R, Logothetis CJ, Neuhausen SL, De Ruyck K, Pandha H, Razack A, Newcomb LF, Fowke JH, Gamulin M, Usmani N, Claessens F, Gago-Dominguez M, Townsend PA, Bush WS, Roobol MJ, Parent MÉ, Hu JJ, Mills IG, Andreassen OA, Dale AM, Seibert TM; UKGPCS collaborators; APCB (Australian Prostate Cancer BioResource); NC-LA PCaP Investigators; IMPACT Study Steering Committee and Collaborators; Canary PASS Investigators; Profile Study Steering Committee; PRACTICAL Consortium.
Nat Commun
DOI:
10.1038/s41467-021-21287-0
Karunamuni RA, Huynh-Le MP, Fan CC, Thompson W, Eeles RA, Kote-Jarai Z, Muir K; UKGPCS Collaborators; Lophatananon A, Tangen CM, Goodman PJ, Thompson IM Jr, Blot WJ, Zheng W, Kibel AS, Drake BF, Cussenot O, Cancel-Tassin G, Menegaux F, Truong T, Park JY, Lin HY, Bensen JT, Fontham ETH, Mohler JL, Taylor JA, Multigner L, Blanchet P, Brureau L, Romana M, Leach RJ, John EM, Fowke J, Bush WS, Aldrich M, Crawford DC, Srivastava S, Cullen JC, Petrovics G, Parent MÉ, Hu JJ, Sanderson M, Mills IG, Andreassen OA, Dale AM, Seibert TM; PRACTICAL Consortium.
Int J Cancer
DOI:
10.1002/ijc.33282
Prostate Cancer
Pihlstrøm L, Fan CC, Frei O, Tan M, Karunamuni RA, Blauwendraat C, Bandres-Ciga S, Gan-Or Z, Grosset DG; International Parkinson's Disease Genomics Consortium (IPDGC); Dale AM, Seibert TM, Andreassen OA.
Genetic Stratification of Age-Dependent Parkinson's Disease Risk by Polygenic Hazard Score
Mov Disord
DOI:
10.1002/mds.28808
Severance LM, Contijoch FJ, Carter H, Fan CC, Seibert TM, Dale AM, McVeigh ER.
J Cardiovasc Comput Tomogr
DOI:
10.1016/j.jcct.2019.05.005
Autoimmune Disorders
Holland D, Brewer JB, Hagler DJ, Fennema-Notestine C, Dale AM; Alzheimer's Disease Neuroimaging Initiative.
Proc Natl Acad Sci U S A
DOI:
10.1073/pnas.0906053106
Tan CH, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Dillon WP, Bonham LW, Yokoyama JS, Karch CM, Brewer JB, Rabinovici GD, Miller BL, Schellenberg GD, Kauppi K, Feldman HA, Holland D, McEvoy LK, Hyman BT, Bennett DA, Andreassen OA, Dale AM, Desikan RS; Alzheimer’s Disease Neuroimaging Initiative.
Acta Neuropathol
DOI:
10.1007/s00401-017-1789-4
Ellinghaus D, Jostins L, Spain SL, Cortes A, Bethune J, Han B, Park YR, Raychaudhuri S, Pouget JG, Hübenthal M, Folseraas T, Wang Y, Esko T, Metspalu A, Westra HJ, Franke L, Pers TH, Weersma RK, Collij V, D'Amato M, Halfvarson J, Jensen AB, Lieb W, Degenhardt F, Forstner AJ, Hofmann A; International IBD Genetics Consortium (IIBDGC); International Genetics of Ankylosing Spondylitis Consortium (IGAS); International PSC Study Group (IPSCSG); Genetic Analysis of Psoriasis Consortium (GAPC); Psoriasis Association Genetics Extension (PAGE); Schreiber S, Mrowietz U, Juran BD, Lazaridis KN, Brunak S, Dale AM, Trembath RC, Weidinger S, Weichenthal M, Ellinghaus E, Elder JT, Barker JN, Andreassen OA, McGovern DP, Karlsen TH, Barrett JC, Parkes M, Brown MA, Franke A.
Nat Genet
DOI:
10.1038/ng.3528
Parkinson's Disease
Neuroimaging AI and Statistical Methods
Shadrin AA, Kaufmann T, van der Meer D, Palmer CE, Makowski C, Loughnan R, Jernigan TL, Seibert TM, Hagler DJ, Smeland OB, Motazedi E, Chu Y, Lin A, Cheng W, Hindley G, Thompson WK, Fan CC, Holland D, Westlye LT, Frei O, Andreassen OA, Dale AM.
Neuroimage
DOI:
10.1016/j.neuroimage.2021.118603
Dale AM, Fischl B, Sereno MI.
Neuroimage
DOI:
10.1006/nimg.1998.0395
Fischl B, Salat DH, Busa E, Albert M, Dieterich M, Haselgrove C, van der Kouwe A, Killiany R, Kennedy D, Klaveness S, Montillo A, Makris N, Rosen B, Dale AM.
Neuron
DOI:
10.1016/s0896-6273(02)00569-x
Fischl B, Sereno MI, Dale AM.
Neuroimage
DOI:
10.1006/nimg.1998.0396